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Tri-Mix Instructions

Injecting yourself with Bi-Mix, Tri-Mix, or Quad-Mix

This serves solely as a recommendation for administering Bi-Mix, Tri-Mix, or Quad-Mix. Before administering any of the injectable treatments, patients should carefully review the appropriate administration methods with their doctor.

Initial Steps

  • Start by washing your hands and ensuring that the penis is clean.
  • Have the following ready to go: syringe, alcohol swab, and an injectable solution bottle.

Using the syringe

  • Using alcohol or alcohol swab, clean the rubber top of the vial that contains tri-mix.
  • Take off the needle cap, allow the syringe to fill with air by setting the plunger to the required dosage.
  • Put the needle into the rubber top of the vial and inject the air. Next, flip the vial upside down ensuring the needle tip is below the surface of the medication.
  • Gradually draw the syringe back to the required dosage.
  • Using your fingers, gently tap the sides of the syringe so that the air bubbles float to the top. Then, make sure to inject the air bubbles out of the syringe prior to using it.
  • Take the needle out of the bottle and place the cap back on it.

Preparation of the site

  • The site of the injection is located between the base of the penis and the mid-portion, specifically at the upper right or upper left sides. Make sure to NOT inject at the midline since it can damage the urethra and arteries/nerves of the penis. Also, make sure to keep away from any arteries or veins that are showing.
  • This is typically within one (1) inch of the base of the penis, near the scrotum.
  • Place the head of the penis near the side of the leg and choose an injection site.
  • Wipe the site using alcohol.

Injecting the penis

  • Gradually go through the skin with the needle at a right angle.  Ensure that the needle is pushed to the end.
  • Inject the tri-mix over a period of several seconds and take out the needle.
  • Compress the site of the injection for a couple minutes.  To stop any possible bleeding, additional time may be necessary.
  • Properly dispose of the syringe and needle in the appropriate container.
  • Basic rules for injection

  • Use the smallest dose that works.  Higher doses may results in more side effects.
  • Injections should be administered no more than three times a week or once every couple days.
  • If an erection lasts longer than 4 hours, find medical help.
  • Sexual stimulation should happen after the injection is administered.

Causes of insufficient response

  • Injected into an incorrect site
  • Agent leaks before injection
  • Stimulation causes premature ejaculation
  • Stress before, during, or after injection
  • Pain – localized – during and/or after the injection procedure
  • Insufficient dose

Steps to resolve insufficient response

  • Re-assess the injection method
  • Re-assess the timing of the injection with regard to sexual activity
  • Have partner present and involved and inject in a relaxed atmosphere
  • Attempt combo therapy with lower PGE-1 doses
  • Re-examine dose with your doctor and if accepted by doctor, raise doses in two to three days or change to a higher dose for optimal results

The information on this website should not be used to diagnose or treat patients without the specific direction and supervision of a physician. You should consult with a physician who knows your medical history and current medical conditions before using Tri-Mix or any erectile dysfunction treatments. Your treatment should be individualized for you by a prescribing physician. Tri-Mix is for the treatment of Erectile Dysfunction and is not approved by the FDA. Tri-Mix requires a prescription and can only be filled at a compounding pharmacy.

Copyright 2011


Mark Drugs Pharmacy 630.529.3400
  • Monday 9:00AM - 5:00PM
  • Tuesday 9:00AM - 5:00PM
  • Wednesday 9:00AM - 5:00PM
  • Thursday 9:00AM - 5:00PM
  • Friday 9:00AM - 5:00PM
  • Saturday Closed
  • Sunday Closed


Mark Drugs Pharmacy 847.419.9898
  • Monday 9:30AM - 6:30PM
  • Tuesday 9:30AM - 6:30PM
  • Wednesday 10:00AM - 2:00PM
  • Thursday 9:30AM - 6:30PM
  • Friday 9:30AM - 6:30PM
  • Saturday 10:00AM - 2:00PM
  • Sunday Closed